Home' SA 50s Lifestyle : SA 50s Winter 14 Contents 16 Winter 2014
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The first ever known vaccine against
a health care associated infection
is being trialled at Flinders Medical
Targeting a bacterium known as
Clostridium diffi cile (C.diff), it is
hoped the worldwide study will
provide an effective preventative
measure for those most at risk of
FMC’s Head of Microbiology and
Infectious Diseases, Professor David
Gordon, said prevention of health
care associated infections, rather
than treatment, was becoming
increasingly important as different
infections increase due to the ageing
population, more chronic disease
and antibiotic resistance.
“Although most people respond
to treatment of C.diff, it is not
uncommon for relapses to occur,”
Professor Gordon said.
“So if we could look at preventing
the infection in the first place, rather
than treating it with antibiotics that
people can become resistant to, this
could be hugely beneficial for our
Most cases of C.diff occur in people
who are taking certain antibiotics
in high doses or over a prolonged
period of time. Some antibiotics can
destroy the “good” bacteria in the
gut, allowing C.diff bacteria to grow.
It is most common in the elderly and
people who have spent extended
periods in health care settings.
C.diff can cause symptoms such as
abdominal pain, diarrhoea, fever and
in severe cases inflammation of the
FMC is the only South Australian
site undertaking the trial. It is open
to people aged 50 years or older,
who have been hospitalised twice
or more in the past year, and taken
People who have an upcoming
surgery requiring a hospital stay for
several days may also be eligible.
Participants receive three doses
of the vaccine or a placebo over a
30-day period. They will then receive
regular follow-ups to assess the
For more information, contact
Study Coordinator Vicki Waddell
on 8204 4292 or email
Testing world-first C.diff vaccine
Beef and lentil bolognese
Try this easy, healthier version of
Bolognese with hidden vegies and
lentils the kids won’t even notice!
Cooking time: 35 minutes
2 tsp olive oil*
1 large onion, chopped
1 large carrot, finely diced
1 stick celery, finely diced
/2 red capsicum, finely diced
500g extra lean beef mince*
/2 cup dry red lentils*
700ml passata sauce*
2 1/2 cups water
2 tsp reduced salt vegetable stock
1 tsp dried oregano leaves
2 tbs chopped fresh basil
500g spaghetti or pasta, cooked, to
*Products available with the Heart
Foundation Tick. Remember
all fresh fruit and vegetables
automatically qualify for the Tick.
1. Heat oil in a large pan, add onion,
carrot, celery and capsicum and
sauté for about 5 minutes or until
vegetables have softened slightly.
2. Add mince, cook over a high heat
until mince is browned all over,
breaking up any large pieces with
a wooden spoon.
3. Stir in lentils, passata sauce,
water, stock powder and oregano
and bring to the boil. Reduce
heat, simmer covered for 10
4. Uncover pan and simmer for
a further 15 minutes or until
sauce has reduced and thickened
slightly, stirring occasionally.
Remove from heat, stir in basil.
Serve with spaghetti or pasta of
Recipe and image reproduced
with permission. © 2013 National
Heart Foundation of Australia.
For other healthier recipe ideas,
recipes or phone 1300 36 27 87.
Nutrients per serve
Total fat (g)
Saturated fat (g)
Are you 50 years of age or older and have you
been hospitalised twice or more in the past
year, and taken antibiotics?
Do you have an upcoming surgery, requiring a
hospital stay for several days?
If you answered YES, you may be at risk of a health care
associated infection from a bacterium known as
Clostridium difficile (C.diff).
Flinders Medical Centre is part of a worldwide study being
conducted by vaccine company Sanofi Pasteur.
The study will try to find out if a new investigational
vaccine can protect at risk individuals like yourself from
For more information about participating in
this study please contact Study Coordinator
Vicki Waddell on 8204 4292 or
This study has been reviewed by Southern Adelaide
Clinical Human Research Ethics Committee.
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